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Why is neostigmine preferred over pyridostigmine? Neostigmine and pyridostigmine are quaternary amines that are incompletely absorbed from the gut. Pyridostigmine is preferred for the treatment of myasthenia gravis because it has a longer duration of action and is less likely to cause unwanted effects.
Can I stop taking pyridostigmine? Your doctor may change your dose, depending on how you respond to the drug. Do not stop taking pyridostigmine without talking to your doctor. Pyridostigmine overdose can cause severe illness, including muscle weakness. It is very hard to tell the difference between too little and too much pyridostigmine.
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How does CellCept work for myasthenia gravis? CellCept works by stopping these antibodies from forming. It directly interferes with DNA replication in immune cells, which slows down the formation of new cells. CellCept reduces the levels of antibodies that attack acetylcholine receptors, thereby improving symptoms of muscle weakness.
Can myasthenia gravis cause death? The most common cause was cardiovascular disease in 31 cases (31%). The myasthenia gravis mortality rate, defined as myasthenia gravis as either an underlying or a contributory cause of death, was 1.4 per million (range 1.1-1.8). Table 2 shows the age and sex specific mortality rates.
Why is gentamicin contraindicated in myasthenia gravis? Aminoglycoside antibiotics impair neuromuscular transmission and can cause clinically significant muscle weakness, resulting in respiratory depression in myasthenia patients. Gentamicin is therefore contraindicated in MG; amikacin, tobramycin, neomycin and streptomycin are also contraindicated.
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